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Multiple system atrophy

Definition:

Multiple system atrophy is a degenerative disorder characterized by the following:

  • Progressive damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions such as blood pressure, heart rate, digestion, and sexual function)
  • Muscle tremor and rigidity
  • Slow movement


Alternative Names:
Shy-Drager syndrome; Neurologic orthostatic hypotension; Shy-McGee-Drager syndrome; Parkinson's plus syndrome

Causes, incidence, and risk factors:

Multiple system atrophy (MSA) is a rare degenerative condition. Its symptoms are similar to those of Parkinson's disease in that patients may move slowly, be tremulous, and have a shuffling gait.

However, in MSA there is more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). There is progressive degeneration of the nervous system, with damage to all parts of the nervous system, including the brain.

The cause is unknown. MSA develops gradually and is most often diagnosed in men older than 60.



Review Date: 1/12/2003
Reviewed By: Elaine T. Kiriakopoulos, M.D., M.Sc., Department of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.

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