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Primary alveolar hypoventilation

Definition:
A rare disorder of unknown cause that leads to inadequate breathing despite normal physiologic make-up.

Alternative Names:
Ondine's curse

Causes, incidence, and risk factors:

The cause of this disease is unknown. Current research is looking at how the brain of these patients may be less responsive to carbon dioxide.

The condition is usually worse during sleep, and periods of apnea (where the breathing stops) are usually present. Patients with this disease are extremely sensitive to even small doses of sedatives or narcotics, which can make their inadequate breathing much worse. The disease primarily affects men 20 to 50 years old. It can also be present in male children.

This condition is commonly seen in those with obesity hypoventilation syndrome.



Review Date: 2/6/2003
Reviewed By: David A. Kaufman, M.D., Pulmonary & Critical Care Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

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